Session 1 : Diversité et rôles écologiques des peptides antimicrobiens et toxines
Amphitheatre GGE
Modérateur : Nicolas Inguimbert, CRIOBE, Perpignan
› Comprendre le rôle écologique des sécrétions venimeuses : une clé pour la valorisation des toxines animales - CONFERENCIER INVITE : Sébastien Dutertre, IBMM, Perpignan
13:45-14:25 (40min)
› Structural and mechanistic insights into RiPP biosynthesis by radical SAM enzymes - Olivier Berteau, Micalis, Jouy-en-Josas
14:25-14:40 (15min)
› Microcins Shape Competition in Poultry Enterobacteriaceae - Angélique Salandre, MCAM & Univ Laval, Paris & Québec
14:40-14:55 (15min)
› Bioassay of the Bacteriocyte-specific Cysteine-Rich defensin BCR4 reveals strong effects on aphid survival, development and symbiosis - Hugo Terrasson, BF2i, Villeurbanne
14:55-15:10 (15min)
› Bioinspired Antimicrobial Strategy: An Extremophile deep sea peptide to combat Cystic Fibrosis infections caused by Pseudomonas aeruginosa and Staphylococcus aureus - Aurélie Tasiemski, CIIL, Lille
15:10-15:25 (15min)
› Characterization of Tryptolinophyllins from the Treefrog Boana boans Expands the Structural and Functional Diversity of the Tryptophyllin Family of Peptides - CONFERENCIER INVITE : Jérôme Leprince, NorDiC, Rouen
15:25-16:05 (40min)
› Peptides inhibiteurs d'histidine kinases pour la lutte contre les bactéries pathogènes résistantes aux antibiotiques - Caroline Giraud, CBSA, Caen
17:15-17:30 (15min)
› Cooperative membrane-active modules drive the translocation of the Bordetella pertussis CyaA toxin - Gaia Scilironi, Institut Pasteur, Paris
17:30-17:45 (15min)
› Implication du peptide antimicrobien LL-37 dans la progression du cancer du sein - Chloé Le Fournis, N2COx, Tours
17:45-18:00 (15min)
› Amyloid-Cationic Peptides as Antimicrobial agents - Sylvie Noinville, LBM, Paris
18:00-18:15 (15min)
Session 3 : Conception, production par synthèse chimique et bioingénierie
Amphitheatre GGE
Modérateur : Baptiste Legrand, IBMM, Montpellier
› Bio-inspired antibacterial agents: mimicking the structural and functional features of PAMs - CONFERENCIERE INVITEE - Sophie Faure, ICCF, Clermont-Ferrand
10:00-10:40 (40min)
› Cell-free protein synthesis for the production and functional characterization of antimicrobial and toxin-derived peptides - Bruno Tillier, Synthelis, Grenoble
10:40-10:55 (15min)
› A straightforward synthetic route toward lipocyclopeptides. Application to antifungal fluorescent echinocandins - Line Bourel, LIT, Strasbourg
10:55-11:10 (15min)
› A (poly)Pro tip for preserving native disulfide connectivity during thiol-maleimide bioconjugation of disulfide-rich peptides - Carlo Pifferi, CBM, Orléans
11:10-11:25 (15min)
› Engineering Therapeutic-Relevant Snake Toxins with Selenocysteine to Investigate Folding and Stability - Chloé Cayrou, CEA, Saclay
11:25-11:40 (15min)
Session 4 : Valorisation des peptides antimicrobiens et toxines
Amphitheatre GGE
Modérateur : Vincent Humblot, Institut FEMTO-ST, Besançon
› A potent inhibitor of HB-EGF derived from the diphtheria toxin for the treatment of crescentic glomerulonephritis - CONFERENCIER INVITE - Daniel Gillet, CEA, Saclay
14:00-14:40 (40min)
› Synergistic Antimicrobial Peptide Combinations to Prevent Biofilm Formation on Implant Surfaces - Emilie Groult, ERRMECe, Cergy
14:40-14:55 (15min)
› Individual and Synergistic Entomotoxic Effects of Naturally Derived AG41 and BCR4 Peptides in the Pea Aphid Acyrtosiphon pisum - Sylvain Benhamou, BF2I, Villeurbanne
14:55-15:10 (15min)
› Fluorescent antimicrobial peptides as tools to study the local polarity of individual layers of the bacterial cell envelope - Anthony Augé, Laboratoire d'Innovation Thérapeutique, Strasbourg
15:10-15:25 (15min)
› Rational approach guided by structural biology to design peptidomimetics inhibiting efflux pumps in Pseudomonas aeruginosa - Hilal Whebi, CiTCoM, Paris
15:25-15:40 (15min)